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Shangzhen Zhou

Shangzhen Zhou, Director, CAROT AAV Vector Core 

Dr. Zhou is the Director of the CAROT Research Vector Core (RVC) with 32 years of experience in biomedical research. She earned her M.D. from Hunan Medical University, and trained in gene therapy research at Indiana University. She is a leading expert in AAV gene therapy research, particularly in innovations of AAV viral vector production. She has published 76 peer-reviewed articles and has been granted 4 patents. She was instrumental in developing the first high titer vector production method with a rapid, serotype independent and high yield purification protocol. Prior to joining CAROT, Dr. Zhou directed RVC at Children's Hospital of Philadelphia, Avigen and Somatix. During her tenure at Avigen as the associate director of new technologies and director of RVC, Dr. Zhou increased the productivity and reduced the cost significantly. Through her effort, Avigen RVC cemented its reputation as the world¹s leading AAV production facility. In addition, she led the company's thalassemia and sickle cell anemia pre-clinical programs. She has also served as the principal scientist at Chiron (now Novartis), overseeing AAV research, therapeutic strategy selection.