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Joan M O'Brien, M.D.

William F. Norris and George E. de Schweinitz Professor of Ophthalmology
Chairman, Department of Ophthalmology, Scheie Eye Institute

Contact information

University of Pennsylvania
Scheie Eye Institute
Department of Ophthalmology
51 N. 39th Street
Philadelphia, PA 19104


BA (Psychology)
Middlebury College, Middlebury, VT, 1979.
Dartmouth Medical School, Hanover, NH, 1986.

Post-Graduate Training

Postbaccalaureate Premedical Studies, Bryn Mawr College, Bryn Mawr, PA, 1980-1982.
Internal Medicine Internship, Beth Israel Hospital, Boston, MA, 1986-1987.
Research Fellow, Internal Medicine (Rheumatology) Harvard Medical School, 1987-1988.
Clinical Fellow, Internal Medicine, Harvard Medical School, Boston, MA, 1987-1988.
Immunology (Rheumatology and Uveitis), Beth Israel Hospital, Boston, MA, 1987-1988.
Clinical Fellow, Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston, MA, 1988-1989.
Research Fellow, Ophthalmic Pathology, Howe Laboratory, Harvard, Whitehead Institute, Mass Institute of Technology, and Cancer Research Center, Mass General Hospital, 1988-1989.
Clinical Fellow, Ophthalmology, Harvard Medical School, Boston, MA, 1988-1992.
Resident, Ophthalmology Residency, Massachusetts Eye and Ear Infirmary, Boston, MA, 1989-1992.
Fellow, Ocular Oncology, Plastics and Orbital Surgery, University of California, San Francisco, 1992-1993.


Diplomate, National Board of Medical Examiners, 1987.
Diplomate, American Board of Ophthalmology, 1996.


Selected Publications

Collins DW, Gudiseva H, Trachtman B, Jerrehian M, Gorry T, Merritt WT, Rhodes A, Sankar Prithvi, Regina M, Miller-Ellis E, O'Brien JM.: Mitochondrial Sequence Variation in African-American Primary Open-Angle Glaucoma Patients. PLOS One 8(10), October 2013.

Shah D, Huang J, Ying G, Pietrobon R, O'Brien J: Trends in Female Representation in Published Ophthalmology Literature from 2000-2009. Digital Journal of Ophthalmology 19(4), September 2013.

Sachidanandam R, Krishnakumar S, Gopal L, O'Brien JM, Khetan V, Sen P.: Full-field electroretinography under general anesthesia in retinoblastoma. Doc Ophthalmol 126(2), January 2013.

Bejjani A, Choi M, Cassidy L, Collins D, O'Brien J, Murray T, Ksander B, Seigel G.: RB116: An RB+ retioblastoma cell line expressing primitive markers. Molecular Vision 2012 18: 2805-2813, November 2012.

Rauschecker AM, Patel CV, Yeom KW, Eisenhut CA, Gawande RS, O'Brien JM, Ebrahimi KB, Daldrup-Link HE: High-resolution MR imaging of the orbit in patients with retinoblastoma. Radiographics 32(5), October 2012.

Khurana A, Eisenhut CA, Wenshua W, Ebrahimi K, Patel C, O'Brien JM, Yeom K, Daldrup-Link H: Comparison of the Diagnostic Value of MR Imaging and Ophthalmoscopy for the Staging of Retinoblastoma. European Society of Radiology October 2012.

Shields C, Ganguly A, O'Brien J, Sato T, Shields J: Uveal Melanoma Trapped in the Temple of Doom. American Journal of Ophthalmology. Elsevier, 154: 219-221, August 2012.

Zheng Y, VanderBeek B, Xiao R, Daniel E, Stambolian D, Maguire M, O'Brien J, Gee J: Retrospective illumination correction of retinal fundus images from gradient distribution sparsity. Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium on IEEE. Page: 972-975, May 2012.

Sachdeva U, O'Brien J: Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma. Journal of Clinical Investigation 122(2): 425-434, February 2012.

Weiduwitlt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL.: Immunochemotherapy with Intensive Consolidation for Primary Central Nervous System Lymphoma: A Pi